You can buy Alfacalcidol (Alfa D3) on this page
1 capsule of Alpha D3 contains 0.25, 0.5, 1.0 μg of alfacalcidol, citric acid, alpha-tocopherol, propyl gallate, ethanol, peanut oil, gelatin, glycerol, mannitol, anisorb, sorbitan, iron oxide yellow, black, red, titanium dioxide, water, black ink.
Capsules soft gelatinous, oval, brownish-red in color according to 0.25, 0.5, 1.0 μg. The contents of alfacalcidol are applied to the capsules in black ink. Packing in blister №10 3 blisters in a cardboard bundle or polypropylene container, cardboard tutu No. 30, 60.pharmachologic effect
Regulator of calcium-phosphorus metabolism, replenishing vitamin D deficiency.
Vitamin, is involved in the regulation of calcium-phosphorus metabolism. It increases the absorption of calcium and phosphorus in the intestine, strengthens their reabsorption in the kidneys, reduces the content of parathyroid hormone in the blood, normalizes the calcium balance in the body. Actively affects the process of bone resorption, normalizes the mineralization of bones. Stimulates the synthesis of bone morphogenetic proteins, which increases its elasticity and reduces the incidence of bone fractures.Alfacalcidol normalizes the growth of muscle tissue and the differentiation of cells of different types improves coordination of movements, increases humoral and cellular immunity.Duration of the drug up to 48 hours.Pharmacokinetics
The drug is rapidly absorbed from the digestive tract. After a single dose of medications, the maximum concentration in the blood is determined after 12 hours.Metabolised in calcitriol, mainly in the liver, in bone tissue - much less. It is not biotransformed in the kidneys. It is excreted approximately in equal parts by kidneys and with bile through the intestine. T1 / 2 -35 hours.
body conditions that require increased vitamin D requirements (osteoporosis, osteomalacia, osteopathy in the presence of renal failure)    prevention and treatment of hypo- and vitamin D vitamin deficiency    unbalanced or malnutrition (vegetarian diet, parenteral nutrition)    lack of ultraviolet irradiation    malabsorption    hypocalcemia on the background of hypoparathyroidism    hereditary hypophosphatemia (rickets D-resistant)    liver failure    Fanconi syndrome, mechanical jaundice, liver cirrhosis    rapid weight loss    multiple pregnancy (according to vital indications).
hypervitaminosis D    hypersensitivity to the components of the drug    hypermagnesia    hypercalcemia    children under 3 years    pregnancy    lactation.Use with caution in atherosclerosis, nephrolithiasis, renal failure, granulomatosis, active form of pulmonary tuberculosis, urolithiasis, heart failure.
heartburn, anorexia, dryness of the oral mucosa, nausea, vomiting, abdominal pain, diarrhea, constipation    fatigue, dizziness, drowsiness, headache, weakness    itching, a rash on the skin    tachycardia    moderately expressed pains in muscles, joints, bones    hypercalcemia, increased concentration of high-density lipoproteins.
Adults: take in the morning 1 time per day, inside. The duration of the course depends on the type of disease, the effectiveness of therapy and is determined individually.In diseases of the gastrointestinal tract, rickets and osteomalacia caused by vitamin D deficiency: 1-3 mcg / day.With CRF, osteodystrophy: 0.25-2 μg / day.In the treatment of osteoporosis: 0.5-1 μg / day.Fanconi Syndrome: 2-6 mcg / day.When osteomalacia and hypophosphatemic rickets: 4-20 mcg / day.When taking Alfa-D3-Teva in order to avoid the development of hypercalcemia, one should monitor the level of calcium in blood and urine once a quarter, monitor the therapeutic effect of the drug and, if necessary, adjust the dose.With an increase in biochemical parameters (plasma alkaline phosphatase content), it is necessary to reduce the dose of the drug or to abolish it before normalization, then you can continue the therapy. Treatment should begin with the appointment of the minimum specified doses, and then the dose can be increased.Important: Instructions for the use of Alpha D3-Teva should be strictly observed, otherwise, an overdose of the drug with the development of side effects.
Early symptoms typical of hypercalcemia (acute hypervitaminosis D): dry mouth, nausea, diarrhea, constipation, anorexia, vomiting, metallic aftertaste, hypercalciuria, fatigue, headache, bone pain, general weakness, myalgia.Late symptoms of hypervitaminosis D: drowsiness, dizziness, heart rhythm disorder, confusion, increased blood pressure, clouding of urine, conjunctival hyperemia, pruritus, nephrolithiasis, photophobia, gastralgia, pancreatitis, psychotic disorders, weight loss.With the development of chronic hypervitaminosis D, calcification of the kidneys, lungs and soft tissues, vessels, and kidney failure is observed.In the early stage of the emergence of the symptoms of acute overdose, it is necessary to cancel the use of Alfa-D3-Teva, wash the stomach. In severe cases - hydration with infusion saline solutions with monitoring the state of the heart, kidney function.
Alfacalcidol in the treatment of osteoporosis can be administered concomitantly with estrogens and preparations that suppress bone resorption. Inducers of liver enzymes (Phenobarbital and phenytoin) reduce the concentration of alfacalcidol in the blood, and inhibitors, on the contrary, increase the concentration (and, possibly, a decrease in its effectiveness). With a simultaneous appointment with drugs, digitalis greatly increases the risk of arrhythmia.When combined with mineral oil, its absorption decreases (for a long time). Alfacalcidol increases the absorption of drugs containing phosphorus and increases the risk of hyperphosphataemia. Simultaneous administration with thiazide diuretics and calcium-containing drugs can cause hypercalcemia.Against the background of treatment it is not recommended to prescribe other analogues of the drug because of the risk of hypercalcemia.Storage conditions
At a temperature of no more than 25 ° C.Shelf life - 36 months
Numerous reviews about the Alpha D3-Teva on the forums indicate its high efficiency in adults and children. The pronounced effect is noted especially by elderly patients with fractures of the upper and lower extremities taking the drug in the recovery period, as well as in the treatment of osteoporosis in patients older than 60 years.High efficiency of Alpha D3-Teva is noted also by parents of children suffering from rickets. The course of taking the drug significantly improves the condition of the musculoskeletal system of the child.
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