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The active ingredient of Escapelle is levonorgestrel, which is present in the preparation at a concentration of 1.5 mg / tab.Effects and assimilation of levonorgestrel optimize the starch present in the tablets (potato and corn), silicon dioxide anhydrous colloid, magnesium stearate, lactose monohydrate, talc.Form of issue
The escapes are available in tablet form. Each package of the preparation is completed with one blister with one white or almost white, flat tablet of round shape. On the tablets there is a chamfer and an engraving "G00" on one side.pharmachologic effect
The drug is a gestagenic agent for postcoital contraception. Suppresses effects caused by estrogen, has a gestagenic effect and prevents the fertilization of the egg.
The Escapelle is a means of emergency postcoital contraception. There is no exact data on how the drug works.The action of levonorgestrel is aimed at inhibiting ovulation and reducing the risk of fertilization of the ovum in the pre-ovulatory phase, when the probability of becoming pregnant is considered to be the highest.Influencing the mucous membrane of the uterus, the substance changes it so that the fertilized egg can not penetrate into it. However, in cases where embryo implantation in the endometrium has already begun, the pills are ineffective.The use of Escapelle after unprotected sexual contact helps prevent pregnancy in about 84% of cases. In this case, the drug does not cause clinically significant violations of carbohydrate and lipid metabolism and does not provoke a violation of vascular-platelet (cellular) and plasma hemostasis.After taking p / os, levonorgestrel is well absorbed in the digestive tract. The indicator of its bioavailability is close to 100%. The maximum concentration of the substance in the blood plasma after a single dose of 0.75 mg is observed after about 1.6 hours (+/- 0.7 hours). As a rule, it is 6.4-21.8 ng / ml.In the blood serum, approximately half of the levonorgestrel that enters the body binds to the albumin protein, and about 47.5% of the substance binds to the SHBG protein (androgen-binding globulin).Levonorgestrel undergoes biotransformation in the liver, the resulting metabolic products are pharmacologically inactive.The half-life is 19.1-29.7 hours. Levonorgestrel and its metabolites are excreted mainly with urine and in small amounts with the contents of the intestine.When breastfeeding with mothers milk, about 0.1% of levonorgestrel enters the baby's body, so if it is used to prevent pregnancy by a breastfeeding woman, lactation should be stopped for 36 hours.
Contraceptive pills Escapelle are designed for emergency contraception. A tablet after an unprotected act, as well as in situations where there are grounds to consider the main method of contraception not sufficiently reliable, should be adopted within the first 72 hours.In particular, it is advisable to take the remedy in case of violation of the integrity of the condom, skipping the pill of the contraceptive for regular use, after rape or coercion to intercourse, as well as in situations where there was a spontaneous sexual act.
In the instructions to the drug manufacturer warns that the reception of Escapelle should be avoided:    in cases when it is known about hypersensitivity to levonorgestrel    patients with lactose intolerance (including those with impaired absorption of glucose and galactose, galactosemia, lactase deficiency)    with severe functional liver failure    to girls younger than 16 years.With caution take Escapelle should women with the syndrome of impaired intestinal absorption.
Receiving tablets Escapelle can be accompanied by a number of side effects, which are most often expressed as:    manifestations of allergies (including swelling of the eyelids and cheeks, the appearance of rashes on the body, scabies, etc.)    disorders of the functions of the digestive system (the most frequent violations are the urge to vomit and / or vomiting, diarrhea)    migraine-like headaches    coordination disorders    discomfort in the lower abdomen    the appearance of bleeding after taking the pill (and these are not associated with menstrual bleeding)    unpleasant sensations in the mammary glands    failure of the menstrual cycle (delay after Escapelle usually ranges from 5 to 7 days).It is believed that side effects of Escapelle are less likely to occur in women who lead an active, healthy lifestyle and go in for sports.Studies of Russian scientists have established that the use of the drug is effective in 97% of cases. In the remaining 3% of cases, the patients took the pill later than 90 hours after unprotected sexual intercourse.Experienced it was possible to determine that about a third of the subjects had a month after receiving the Escapelle did not start in the usual time, but 7-14 days later. In 14% of subjects, menstrual bleeding after taking the pill was significantly more abundant than usual.In 16% of subjects, menstruation started earlier than expected desires for vomiting arose in 11%, vomiting - in 3%, breast tenderness - in 3% of women who took part in the experiment. In general, one or other side effects were observed in 17% of the participants in the experiment.
According to the instruction on Escapelle, the tablets should be taken orally, with enough drinking water.The tablet is allowed to drink without being tied to the time of ingestion, and on any day of the cycle (provided that the previous menstrual bleeding has passed normally), but as soon as possible after unprotected sexual intercourse. The maximum allowed interval between sexual intercourse and tablet intake is 72 hours.If within 3 hours after taking the drug a woman has vomiting, you need to drink another pill.After the application of Escapelle, barrier means of contraception should be used.Menstruation after taking the medication usually starts at the usual time, but the possibility of a minor cycle failure (bleeding can begin as a few days earlier, and a few days later) is possible.How often can I take the drug? The instruction for Escapelle states that it is optimal to take no more than 1 tablet during one menstrual cycle. To avoid negative consequences, Escapelle is recommended to drink no more often than once every 3-6 months.It should be noted that the use of the drug does not exclude the need to use additional means of protection against diseases that are sexually transmitted.
The consequences of taking high doses of Escapelle are expressed as an increase in the side effects described in the instructions to the drug.There is no specific antidote for levonorgestrel, treatment is symptomatic.
Simultaneous use of the drug with inducers of hepatic enzymes provokes an increase in the metabolism of levonorgestrel.Reduction of the contraceptive effect of Escapelle is facilitated by taking the drug in combination with: barbiturates (Carbamazepine, Primidon, Phenytoin) means, which include St. John's wort (holed) Amprenavir, Oxycarbazepine, Lansoprazole, Topiramate, Rifampicin, Nevirapine, Tacrolimus, Tretinoin, tetracycline and ampicillin group agents, Ritonavir, Griseofulvin, Rifabutin.In turn, pills reduce the effectiveness of anticoagulants and hypoklikemic drugs, increase the plasma concentration of glucocorticosteroids and increase the risk of toxicity of cyclosporine by suppressing its metabolism.Terms of sale
The prescription is not requered if you buy Escapelle online.Storage conditions
Tablets should be stored at a temperature of 15-25 ° C. Keep away from children.Shelf life - 5 years.
It is necessary to avoid repeated use of the drug during one cycle, since this is associated with a high probability of menstrual function disorders.Regular use of the contraceptive means provokes an increase in the incidence of side effects and a decrease in the effectiveness of tablets.If a woman does not have a monthly dose after taking the Escapelle tablets (this applies to cases when menstrual bleeding does not begin within a week after the use of the drug), a checkup should be performed to exclude pregnancy.Reasons for seeking a doctor are also a change in the nature of discharge, the appearance of pain in the lower abdomen, fainting. Similar symptoms can be a sign of ectopic (ectopic) pregnancy.In the case of development of uterine bleeding, a gynecological examination is necessary.In adolescence (up to 16 years), emergency contraception with the use of Escapelle is possible in exceptional cases (for example, with rape) and only when approved by the attending physician.
In the instructions to the preparation, the manufacturer does not describe the consequences of its use in combination with alcohol.As a rule, such a combination is not accompanied by serious complications. However, given that the processing of levonorgestrel is responsible for the kidneys, intestines and liver, it should be reported that with simultaneous use of Escapelle with alcoholic beverages, the load on these organs significantly increases.
Pregnancy is a contraindication to the use of Escapelle. The available data indicate the absence of adverse effects of levonorgestrel on the fetus in the case of pregnancy with the use of post-coital contraception.
The feedback about the Escapelle left by buyers is quite diverse: someone praises the remedy for its high efficiency, someone scolds for the fact that the product caused a lot of side effects, and sometimes does not help at all.The consequences of Escapelle - and the testimonies about this drug are a confirmation - are often expressed quite clearly: in some women, the pill taken provoked nausea, headaches, vomiting, severe pain in the abdomen, someone noted the appearance of white discharge after applying the drug and strong weakness, and in some cases, Escapelle was the cause of quite serious hormonal failures.Gynecologists in the reviews of this drug indicate that the remedy today is considered one of the most effective and safe.At the same time, having got into the body, Escapelle is completely eliminated from it within 24 hours. This property allows you to apply it even with lactation (a mandatory condition is a temporary one - for 36 hours - its termination).The doctors' comments about Escapelle, compiled on the basis of these studies, indicate that the use of levonorgestrel 1.5 mg is tolerated well enough by a woman, and side effects develop only in every sixth case. And in most cases they are similar to the sensations that women experience in the first weeks of pregnancy.Experts believe that the main advantage of the drug is that it can be taken without preliminary examinations and testing. In addition, when it is used completely no cumulative effect, and the recommended dose does not affect the coagulation factors and does not provoke serious violations of carbohydrate and lipid metabolism.'
|The purpose of the medication||Contraception|