You can buy Siluette contraceptive pills on this page
In 1 tablet of dienogest 2 mg and ethinyl estradiol 0.03 mg.Lactose, corn starch, hypromellose, talc, magnesium stearate, potassium polacrilin, as auxiliary substances.Form of issue
Tablets in the shell number 21.pharmachologic effect
Siluette - a combined drug with anti-androgenic and contraceptive effects. Antiandrogenic effect is due to a decrease in the level of androgens in the blood. Taking this combination eliminates the symptoms of acne and seborrhea.Inhibition of ovulation, changes in the structure of the endometrium and increased viscosity of the cervical secret under the action of active substances provide reliable contraception. Dienogest - a derivative of norethisterone in a dose of 1 mg inhibits ovulation. Does not have a significant mineralocorticoid and glucocorticoid action.Pharmacokinetics
Ethinyl estradiol is rapidly absorbed in the intestine, and the maximum concentration is determined after 1.5-4 hours. Bioavailability is 44%. Almost completely binds to albumins. Equilibrium concentration is achieved in the second half of the cycle. Much of it is metabolized in the liver.Excretion of metabolites takes place in 2 stages: their concentration decreases after 1 hour and finally after 10-20 hours. Metabolites are excreted by the liver and kidneys.Dienogest is also rapidly absorbed in the intestine and after 2.5 hours the maximum concentration is determined in the blood. Bioavailability reaches 96%. Equilibrium concentration is achieved in 4 days.It binds to blood albumins. Metabolized by hydroxylation, metabolites are inactive and very quickly removed from the plasma. The elimination half-life is 9 hours. The most part is excreted by the kidneys.Indications for use
It is used to treat acne and for contraception.
The drug Syluet is contraindicated when:    hypersensitivity    thrombophlebitis and deep vein thrombosis    angina pectoris    ischemic attacks    pancreatitis    liver diseases and jaundice    severe arterial hypertension    severe dyslipoproteinemia    diabetes mellitus with vascular complications    uterine bleeding of unknown origin    epilepsy    pregnancy    breastfeeding.
Frequent undesirable reactions that can cause the drug Siluette:    headache    nausea, vomiting    pain in the mammary glands, an increase in them    backache    cramps of the calf muscles    increased appetite    menstrual like bleeding    weight gain    decreased mood    venous thromboembolism.Rarely encountered reactions:
dizziness    abdominal pain    diarrhea, gastritis    anemia    tachycardia    increased excitability    impaired vision, dry eye mucosa    noise in the ears, hearing loss    sinusitis, bronchitis    acne    vaginitis and fungal infections    phlebeurysm    weakness    influenza-like symptoms    allergic reactions    insomnia    arthralgia, pain in the muscles.
Tablets are taken orally, one daily, in the prescribed order, 21 days. Tablets from a new package are taken after a one-week break. At this time, bleeding cancellation occurs.If the drug is taken for the first time, then it should be started on the 1st day of menstruation.When switching from other combined funds, they start receiving after a normal break.After the abortion in the first trimester begin to take immediate effect. After birth - on the 21st day.If the tablet intake is missed and the skip time is less than 12 hours, do not worry about reducing contraceptive protection. However, you need to take a pill faster. Reception can not be interrupted for more than 7 days.The instruction contains complete information on how to drink the drug in other situations, how to delay the bleeding cancellation and in which cases additional contraceptive measures are needed.Overdose
With strict adherence to the instructions, Siluette does not cause an overdose.
Breakthrough bleeding may occur with simultaneous administration with hydantoin, carbamazepine, phenobarbital, rifampicin, efavirenz, rifabutin, ritonavir, nevirapine, felbamate, griseofulvin, St. Johns wort preparations.Reduction of the effectiveness of contraception is observed with the appointment simultaneously with ampicillin, rifampicin and tetracycline, therefore at this time it is necessary to use barrier methods of contraception. After taking rifampicin, it is necessary to apply additional contraception for a longer time (28 days).Storage conditions
Storage temperature up to 25 ° C.Shelf life - 2 years.
The choice of oral contraceptives should not be based on because it is cheaper" or "because a friend advised." Someone will use microdosed, and someone low-dose, so they are appointed after the examination of hormones, and always take into account gynecological diseases and factors that increase the risk of venous / arterial thrombotic events. This age, hereditary predisposition, arterial hypertension, lower limb operations, obesity, smoking (especially women 35 years and older). If you can not quit smoking, you need to apply another method of contraception.Sweet refers to low-dose contraceptives, which are usually prescribed to nulliparous women. Its anti-androgenic action comes to the fore. Dienogest is a progestin, which is most often prescribed with a therapeutic purpose for endometriosis and erosion. Therefore, first of all - this is a medicinal preparation. Usually it is well tolerated, but some women in their responses note the presence of adverse reactions."... Assigned to endometriosis for six months. The treatment was well, the pain and spotting disappeared after the first month of admission. ""... With erosion, the cervix was prescribed this remedy. I noticed that the monthly ones became scarce. ""... There were very painful periods, so they prescribed this drug. Has spent on drink 3 months and the cycle was normalized, monthly without a pain, and on weight has not affected "."... I accepted Yarin, but now I switched to this remedy. I see no difference, but its much cheaper. ""... I am very pleased with this drug, I approached. Ive been drinking for a month and really like it. ""... Three days later, I began to feel sick, vomiting. Then there were pains in the liver. The doctor canceled the drug. ""... I did not fit. Walked like in a fog and there was dizziness. ""... Nausea and pain in the stomach disturbed me.""... My chest began to hurt and there were pains in the lower abdomen."It must be remembered that the reorganization of the body and its "habituation" to any contraceptive can be three cycles and if the reactions are not very pronounced, then there is no need to worry. The most common side effect at this time are spotting, but the contraceptive effect does not decrease. If the bleeding continues after the adaptation period at the beginning and middle of taking the tablets out of the package, then it means that the estrogen is not enough and the dosage should be increased by selecting the appropriate drug. If the bleeding at the end is a shortage of gestagens, another remedy is also chosen, but with a larger dose of the progestogen component."
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